04/28/2025
Editorial
Alison Farrell, on behalf of the PLOS Medicine Editors, discusses how adopting the recommendations in the updated CONSORT and SPIRIT 2025 statements for reporting randomised clinical trials and protocols can help improve confidence in the transparency of clinical trials.
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Browse Issues 2004 – 2025
04/28/2025
Guidelines and Guidance
The SPIRIT 2025 statement provides updated guidance to improve the comprehensiveness and quality of clinical trial protocols that can ultimately aid in trial design and reproducibility.
Image credit: Mohamed Hassan, Pixabay
04/07/2025
Research Article
Heather Wightman and colleagues investigate the association between frailty and efficacy and safety of SGLT2 inhibitors, GLP1 receptor agonists, and DDP4 inhibitors in patients with type 2 diabetes.
Image credit: Sweet Life, Unsplash
03/31/2025
Research Article
Reina Tonegawa-Kuji and colleagues present an updated meta-analysis of cognitive outcome and side effects of anti-amyloid beta monoclonal antibodies from phase III randomized controlled trials in patients with sporadic Alzheimer's disease.
Image credit: Mohamed Hassan, Pixabay
04/15/2025
Research Article
Milou MF Schuurbiers, Christopher G Smith and colleagues validate a tissue-based personalized ctDNA assay to predict recurrence in patients with non-small cell lung cancer in a new independent group of patients.
Image credit: David Sánchez-Medina Calderón, Pixabay
04/17/2025
Research Article
Using electronic health records from the TriNetX network, Teng-Li Lin and colleagues compare the risk of cardiovascular disease in patients with psoriasis who were prescribed biologic versus oral therapies.
Image credit: Piyapong Sayduang, Pexels
04/29/2025
Research Article
By Sehoon Park, Soomin Chung, and colleagues.
Image credit: Robina Weermeijer, Unsplash
04/15/2025
Research Article
Anh Tran and colleagues assess the safety profile the macrolide class of antibiotics taken during the first trimester of pregnancy.
Image credit: cottonbro studio, Pexels
04/17/2025
Research Article
By members of Global Health & Population Project on Access to Care for Cardiometabolic Diseases.
Image credit: Nataliya Vaitkevich, Pexels
04/17/2025
Research Article
By Chun-Hsien Lin and colleagues.
Image credit: Olena, Pixabay
In this Editorial, Guest Editors Timothy R. Walsh, Ana C. Gales, Ramanan Laxminarayan, and our PLOS Medicine Editor Philippa C. Dodd discuss the Special Issue dedicated to Antimicrobial resistance and emphasize the urgent threat of AMR.
Ruchita Balasubramanian and colleagues, estimate the incidence of hospital-associated infections resistant to antibiotics in 195 countries using point prevalence survey data.
James Neal Russell and colleagues explore antibiotic use and mortality prediction in hospitalised neonates and infants with sepsis.
Silvia Bertagnolio, Amitabh Bipin Suthar, Olga Tosas and Kitty Van Weezenbeek discuss surveillance of antimicrobial resistance, the existing limitations and the implications this has on accurate determination of incidence.
Yin Mo and colleagues investigate implications of antibiotic duration on antibiotic resistance in hospitals.
In this Special Issue, we present a fascinating array of research papers providing insights into various facets of mental health during the pandemic.
This collection of research articles highlights the multi-faceted challenges imposed by drug-resistant bacteria, the consequences for health and economics, and interventions that could lessen the burden.
In this Collection, PLOS Medicine presents high-quality translational research and clinical studies on advances in early cancer detection.
This Special Issue brings together the latest research on child and adolescent health, including strategies to monitor and combat child mortality from birth through adolescence, and environmental impacts on child health and mortality.
This 2019 Special Issue highlights the importance of nutrition for maternal and child health.
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